Njengekhemikhali eluthayo futhi eyingozi kakhulu, iNicotine ingabangela ukwanda ngokweqile komfutho wegazi, ukushaya kwenhliziyo, ukugeleza kwegazi enhliziyweni kanye nokuncipha kwemithambo. Kungase futhi kube nomthelela ekuqineni kwezindonga ze-arterial lapho, bese kungabangela ukuhlaselwa yinhliziyo.