Njengekhemikhali ekhobokisayo kwaye iyingozi kakhulu, inikotini inokubangela ukunyuka okugqithisileyo koxinzelelo lwegazi, ukubetha kwentliziyo, ukuhamba kwegazi entliziyweni kunye nokucutheka kwemithambo. Inokuthi ifake isandla ekuqineni kweendonga ze-arterial xa ngokulandelelanayo, emva koko inokubangela ukuhlaselwa yintliziyo.