ʻO ka hopena o ka hopena i kahi mea nui loa o ka inctictide gectically a me ka piliʻana i nā hopena a me ka'ōpū o ka'ōpū, a me nā hopena ākea. Hiki ke hoʻohanaʻia ma nā lole, nā lāʻau hua, Teakcats, Tamporoms, nā mea kanu lāʻau, kelepa, nā moike nui, ka poʻe lawe a me nā huluhulu He hopena mutagenic ma luna o nā kānaka, hōʻino i ka'ōnaehana o ke kikowaena waena, aʻo ia kahi mea hoʻokūkū nui. Ma muli o kāna hanaʻana i ka mea aloha, bioccumulation a me ka hopena e hoʻonāukiuki i nā hopena, ua pāpāʻia kona hoʻohana ma mua o 50 mau'āina.